Yes
I should really just call them a ShortStop, as most do, but its just like saying "BandAid".
The Shortstop breaker, when connected properly, will protect the Battery and electrical system.
With the VR connected to the brass lug side if the VR goes bat shit on you then it will trip the breaker instantly thus protecting the system.
I did some real world testing and found that while the breaker will trip in both directions it only trips instantly in one direction and that is when the overload is applied to the brass lug side first. If it is applied to the silver lug side first it would take up to 2 seconds to trip and that was only with the 25 amp breaker. The 40 amp breaker would trip instantly if the overload was applied to the brass side but I felt insecure leaving the overload on the silver side for more than 3 seconds, I was afraid it would ruin the battery I was using for testing, and it still had not tripped.
So having said all of the above the reality may be that the fuse is probably the best route since in the end BD was starting to use this:
Cleaner, more compact, water proof and vibration resistant but might not fit every model and year.